Article
Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli.
The American journal of pathology - 1 Jun 2003
Woodman Scott E, Ashton Anthony W, Schubert William, Lee Hyangkyu, Williams Terence M, Medina Freddy A, Wyckoff Jeffrey B, Combs Terry P, Lisanti Michael P
Abstract excerpt
Recent studies have shown that caveolin-1 (Cav-1) plays an important role as a regulator of angiogenesis in vitro. Here, we use Cav-1 knockout (KO) mice as a model system to examine the in vivo relevance of these findings. A primary mediator of angiogenesis is basic fibroblast growth factor (bFGF). Thus, we studied bFGF-induced angiogenesis in Cav-1 KO mice using a reconstituted basement membrane system, ie,...
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