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Article

The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.

International journal of cancer - 15 Mar 2015

Izraely Sivan, Sagi-Assif Orit, Klein Anat, Meshel Tsipi, Ben-Menachem Shlomit, Zaritsky Assaf, Ehrlich Marcelo, Prieto Victor G, Bar-Eli Menashe, Pirker Christine, Berger Walter, Nahmias Clara, Couraud Pierre-Olivier, Hoon Dave S B, Witz Isaac P

Abstract excerpt

Brain metastases occur frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain metastasis development are not well understood. Identification of molecular determinants regulating melanoma brain metastasis would advance the development of prevention and therapy strategies for this disease. Gene expression profiles of cutaneous and...

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Identifiers

PMID: 25046141
DOI: 10.1002/ijc.29090

Genes

CLDN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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