Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation.

PloS one - 1 Jan 2013

Hofkens Wouter, Schelbergen Rik, Storm Gert, van den Berg Wim B, van Lent Peter L

Abstract excerpt

BACKGROUND: To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis. MATERIAL AND METHODS: Experimental arthritis (antigen and immune complex induced) was elicited in mice and prednisolone containing liposomes were given systemically. Synovium was investigated using microarray analysis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Antibody Complex
Share to Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Experimental

Share to Liposomes

Share to Macrophage Activation

Share to Macrophages

Share to Prednisolone

Share to Synovial Membrane

Source

Open in PubMed Open full text

Identifiers

PMID: 23468840
DOI: 10.1371/journal.pone.0054016
PMCID: PMC3585322

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation.PMID 23468840Read ↗

The role of macrophage polarization in rheumatoid arthritis and osteoarthritis: Pathogenesis and therapeutic strategiesSemantic proximity Read ↗

The Contribution of Macrophage Plasticity to Inflammatory Arthritis and Their Potential as Therapeutic TargetsSemantic proximity Read ↗

Research Advances in Targeted Modulation of Macrophage M1/M2 Polarization for the Treatment of Rheumatoid ArthritisSemantic proximity Read ↗

Advances in research on M1/M2 macrophage polarization in the pathogenesis and treatment of osteoarthritisSemantic proximity Read ↗

Macrophage and chondrocyte phenotypes in inflammation.Semantic proximity Read ↗

Tuning Monocytes and Macrophages for Personalized Therapy and Diagnostic Challenge in Rheumatoid Arthritis.Semantic proximity Read ↗

Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis?Semantic proximity Read ↗

Phenotypic alteration of macrophages during osteoarthritis: a systematic review.Semantic proximity Read ↗

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis.Semantic proximity Read ↗

Guiding synovial inflammation by macrophage phenotype modulation: an in vitro study towards a therapy for osteoarthritis.Semantic proximity Read ↗

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype.Semantic proximity Read ↗

S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.