Article
Expression, subunit composition, and function of AMPA-type glutamate receptors are changed in activated microglia; possible contribution of GluA2 (GluR-B)-deficiency under pathological conditions.
Glia - 1 Jun 2013
Beppu Kaoru, Kosai Yuki, Kido Mizuho A, Akimoto Nozomi, Mori Yuki, Kojima Yuichiro, Fujita Kyota, Okuno Yuko, Yamakawa Yukiko, Ifuku Masataka, Shinagawa Rika, Nabekura Junichi, Sprengel Rolf, Noda Mami
Abstract excerpt
Microglia express AMPA (α-amino-hydroxy-5-methyl-isoxazole-4-propionate)-type of glutamate (Glu) receptors (AMPAR), which are highly Ca(2+) impermeable due to the expression of GluA2. However, the functional importance of AMPAR in microglia remains to be investigated, especially under pathological conditions. As low expression of GluA2 was reported in some neurodegenerative diseases, GluA2(-/-) mice were used to...
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