Article
An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013
Poddar Darshana, Basu Abhijit, Baldwin William M, Kondratov Roman V, Barik Sailen, Mazumder Barsanjit
Abstract excerpt
Inflammation is an obligatory attempt of the immune system to protect the host from infections. However, unregulated synthesis of proinflammatory products can have detrimental effects. Although mechanisms that lead to inflammation are well appreciated, those that restrain it are not adequately understood. Creating macrophage-specific L13a-knockout mice, we report that depletion of ribosomal protein L13a abrogates...
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