Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

16 Nov 2009

Abstract excerpt

Essential effector functions of innate immunity are mediated by complement activation initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL) and the ficolins. We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1.4 microg/ml in Ca(2+)-dependent complexes with the soluble pattern recognition molecules. The affinity for MBL is in the nanomolar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Invertebrate Immune Response Mechanisms
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19917686
DOI: 10.4049/jimmunol.0902388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement ActivationPMID 19917686Read ↗

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)Semantic proximity Read ↗

A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement ActivationSemantic proximity Read ↗

MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.Semantic proximity Read ↗

Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations.Semantic proximity Read ↗

Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement PathwaySemantic proximity Read ↗

Two Constituents of the Initiation Complex of the Mannan-Binding Lectin Activation Pathway of Complement Are Encoded by a Single Structural GeneSemantic proximity Read ↗

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend.Semantic proximity Read ↗

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19Semantic proximity Read ↗

A journey through the lectin pathway of complement—<scp>MBL</scp> and beyondSemantic proximity Read ↗

Membrane Cofactor Protein (MCP or CD46): Newest Member of the Regulators of Complement Activation Gene ClusterSemantic proximity Read ↗

Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity.Semantic proximity Read ↗

Biochemistry and genetics of mannan-binding lectin (MBL)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.