Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bio-inspired liposomal thrombomodulin conjugate through bio-orthogonal chemistry.

Bioconjugate chemistry - 17 Apr 2013

Zhang Hailong, Weingart Jacob, Jiang Rui, Peng Jianhao, Wu Qingyu, Sun Xue-Long

Abstract excerpt

We report the synthesis of bioinspired liposomal thrombomodulin (TM) conjugates by chemoselective and site-specific liposomal conjugation of recombinant TM at C-terminus. TM is an endothelial cell membrane protein that acts as a major cofactor in the protein C anticoagulant pathway. To closely mimic membrane protein structural features of TM, we proposed membrane-mimetic re-expression of recombinant TM onto...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomimetics
Share to Fluorescent Dyes
Share to EGF gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liposomes

Share to Molecular Structure

Share to Mutation

Share to Recombinant Proteins

Share to Thrombomodulin

Source

Open in PubMed Open full text

Identifiers

PMID: 23458546
DOI: 10.1021/bc300399f
PMCID: PMC3630279

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Bio-inspired liposomal thrombomodulin conjugate through bio-orthogonal chemistry.PMID 23458546Read ↗

Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluidSemantic proximity Read ↗

Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo.Semantic proximity Read ↗

A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates.Semantic proximity Read ↗

In Silico Screening Using Freely Available Computational Tools to Generate Novel Peptide/Protein Pairs for Protein-Protein Ligation.Semantic proximity Read ↗

Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells.Semantic proximity Read ↗

Construction and characterization of a t-PA mutant for use in ATTEMPTS: a drug delivery system for achieving targeted thrombolysis.Semantic proximity Read ↗

Control of a tyrosyl radical mediated protein cross-linking reaction by electrostatic interaction.Semantic proximity Read ↗

Multiple Mutations on α, β and γ Domains of Streptokinase Lead to the Generation of Highly Efficient Cysteine Analogues with Promising Features.Semantic proximity Read ↗

Probing ligand binding to thromboxane synthase.Semantic proximity Read ↗

Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I.Semantic proximity Read ↗

Synthesis and single enzyme activity of a clicked lipase-BSA hetero-dimer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.