Article
Multiple Mutations on α, β and γ Domains of Streptokinase Lead to the Generation of Highly Efficient Cysteine Analogues with Promising Features.
Current pharmaceutical biotechnology - 1 Jan 2023
Alinodehi Narges Norouzzadeh, Behrooz Hamideh, Sabaei Milad, Nezamiha Farahnaz Khoshdel, Mianroodi Reza Arabi
Abstract excerpt
BACKGROUND: Streptokinase, one of the most widely used thrombolytic medicines, is a favorable protein for site-specific PEGylation as it lacks any cysteine residues in its amino acid sequence; however, any changes in the protein's structure should be carefully planned to avoid undesired changes in its function. OBJECTIVES: This study aimed to design and produce novel di/tri-cysteine variants of streptokinase from...
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