Article
Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I.
Cancer science - 1 Jul 2012
Miura Shigenori, Kondo Jun, Kawakami Toru, Shukunami Chisa, Aimoto Saburo, Tanaka Hideyuki, Hiraki Yuji
Abstract excerpt
Chondromodulin-I (ChM-I) is a 25-kDa glycoprotein in cartilage matrix that inhibits angiogenesis. It contains two distinctive structural domains: the N-terminal third of the molecule is a hydrophilic domain that contains O-linked and N-linked oligosaccharide chains, and the C-terminal two-thirds is a hydrophobic domain that contains all of the cysteine residues. In the present study, we have attempted to further...
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