Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.

Stem cell research - 1 May 2013

Yao Yong-Gang, Kajigaya Sachiko, Feng Xingmin, Samsel Leigh, McCoy J Philip, Torelli Giuseppe, Young Neal S

Abstract excerpt

Marked sequence variation in the mtDNA control region has been observed in human single CD34(+) cells, which persist in vivo and are present also in differentiated hematopoietic cells. In this study, we analyzed 5071 single CD34(+) cells from 49 individuals (including 31 maternally related members from four families and 18 unrelated donors) in order to determine the mutation spectrum within the mtDNA control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, CD34

Share to DNA, Mitochondrial

Share to Haplotypes

Share to Leukocytes, Mononuclear

Share to Pedigree

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 23455392
DOI: 10.1016/j.scr.2013.01.006
PMCID: PMC4154056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.PMID 23455392Read ↗

Mitochondrial DNA mutations in single human blood cells.Semantic proximity Read ↗

Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes.Semantic proximity Read ↗

Mitochondrial DNA sequence variation in single cells from leukemia patients.Semantic proximity Read ↗

Mechanism of age-related accumulation of mitochondrial DNA mutations in human bloodSemantic proximity Read ↗

Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes.Semantic proximity Read ↗

Variant load of Mitochondrial DNA in single human Mesenchymal stem cellsSemantic proximity Read ↗

Where and when do somatic mtDNA mutations occur?Semantic proximity Read ↗

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs.Semantic proximity Read ↗

Variant load of mitochondrial DNA in single human mesenchymal stem cells.Semantic proximity Read ↗

Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport.Semantic proximity Read ↗

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background.Semantic proximity Read ↗

Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.