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Article

Targeting Pan-ETS Factors Inhibits Melanoma Progression

1 Feb 2021

Abstract excerpt

The failure of once promising target-specific therapeutic strategies often arises from redundancies in gene expression pathways. Even with new melanoma treatments, many patients are not responsive or develop resistance, leading to disease progression in terms of growth and metastasis. We previously discovered that the transcription factors ETS1 and PAX3 drive melanoma growth and metastasis by promoting the...

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PMID: 33526511
DOI: 10.1158/0008-5472.can-19-1668

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