Article
Oncogenic B-Raf(V600E) abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells.
Cancer letters - 28 Aug 2013
Zhang Ling, Shi Ruyi, He Chanting, Cheng Caixia, Song Bin, Cui Heyang, Zhang Yanyan, Zhao Zhiping, Bi Yanghui, Yang Xiaofeng, Miao Xiaoping, Guo Jiansheng, Chen Xing, Wang Jinfen, Li Yaoping, Cheng Xiaolong, Liu Jing, Cui Yongping
Abstract excerpt
Activating B-Raf mutations that deregulate the mitogen-activated protein kinase (MAPK) pathway commonly occur in cancer. Although B-Raf(V600E) induces increased Mps1 protein contributing to centrosome amplification and chromosome instability, the regulatory mechanisms of Mps1 in melanoma cells is not fully understood. Here, we report that Mps1/AKT and B-Raf(WT)/ERK signaling form an auto-regulatory negative...
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