Article
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.
Genes & development - 15 May 2017
Fell Stuart M, Li Shuijie, Wallis Karin, Kock Anna, Surova Olga, Rraklli Vilma, Höfig Carolin S, Li Wenyu, Mittag Jens, Henriksson Marie Arsenian, Kenchappa Rajappa S, Holmberg Johan, Kogner Per, Schlisio Susanne
Abstract excerpt
We recently identified pathogenic KIF1Bβ mutations in sympathetic nervous system malignancies that are defective in developmental apoptosis. Here we deleted KIF1Bβ in the mouse sympathetic nervous system and observed impaired sympathetic nervous function and misexpression of genes required for sympathoadrenal lineage differentiation. We discovered that KIF1Bβ is required for nerve growth factor (NGF)-dependent...
Topics
- Animals
- Apoptosis
- Cell Differentiation
- Cell Line, Tumor
- Gene Expression Regulation, Developmental
- Gene Silencing
- Kinesins
- Mutation
- Neuroblastoma
- Neurodegenerative Diseases
- Neurofibromin 1
- Neurons