Article
Early folding events protect aggregation-prone regions of a β-rich protein.
Structure (London, England : 1993) - 5 Mar 2013
Budyak Ivan L, Krishnan Beena, Marcelino-Cruz Anna M, Ferrolino Mylene C, Zhuravleva Anastasia, Gierasch Lila M
Abstract excerpt
Protein folding and aggregation inevitably compete with one another. This competition is even keener for proteins with frustrated landscapes, such as those rich in β structure. It is interesting that, despite their rugged energy landscapes and high β sheet content, intracellular lipid-binding proteins (iLBPs) appear to successfully avoid aggregation, as they are not implicated in aggregation diseases. In this...
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