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Article

Understanding the role of the Q338H MUTYH variant in oxidative damage repair.

Nucleic acids research - 1 Apr 2013

Turco Eleonora, Ventura Ilenia, Minoprio Anna, Russo Maria Teresa, Torreri Paola, Degan Paolo, Molatore Sara, Ranzani Guglielmina Nadia, Bignami Margherita, Mazzei Filomena

Abstract excerpt

The MUTYH DNA-glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-2'-deoxyguanine (8-oxodG) lesion by removing adenine erroneously incorporated opposite the oxidized purine. Inherited biallelic mutations in the MUTYH gene are responsible for a recessive syndrome, the MUTYH-associated polyposis (MAP), which confers an increased risk of colorectal cancer. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23460202
DOI: 10.1093/nar/gkt130
PMCID: PMC3627602

Genes

MUTYH
HUS1
RAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Understanding the role of the Q338H MUTYH variant in oxidative damage repair.PMID 23460202Read ↗

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