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Article

Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.

The Journal of biological chemistry - 7 Mar 2014

Dorn Julia, Ferrari Elena, Imhof Ralph, Ziegler Nathalie, Hübscher Ulrich

Abstract excerpt

Oxidation of DNA is a frequent and constantly occurring event. One of the best characterized oxidative DNA lesions is 7,8-dihydro-8-oxoguanine (8-oxo-G). It instructs most DNA polymerases to preferentially insert an adenine (A) opposite 8-oxo-G instead of the appropriate cytosine (C) thus showing miscoding potential. The MutY DNA glycosylase homologue (MutYH) recognizes A:8-oxo-G mispairs and removes the...

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Identifiers

PMID: 24443563
DOI: 10.1074/jbc.M113.536094
PMCID: PMC3945365

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