Accuracy of p53 codon 72 polymorphism status determined by multiple laboratory methods: a latent class model analysis.

Abstract excerpt

INTRODUCTION: Studies on the association of a polymorphism in codon 72 of the p53 tumour suppressor gene (rs1042522) with cervical neoplasia have inconsistent results. While several methods for genotyping p53 exist, they vary in accuracy and are often discrepant. METHODS: We used latent class models (LCM) to examine the accuracy of six methods for p53 determination, all conducted by the same laboratory. We also...

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