Article
The p53 codon 72 polymorphism and risk of high-grade cervical intraepithelial neoplasia.
Cancer detection and prevention - 1 Jan 2005
Koushik Anita, Ghosh Anirban, Duarte-Franco Eliane, Forest Pierre, Voyer Hélène, Matlashewski Greg, Coutlée François, Franco Eduardo L
Abstract excerpt
BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk. However, research on this topic has been contentious, which prompted us to carry out a case-control study in the Montreal area. METHODS: Cases were women with histologically-confirmed high-grade...
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