Article
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies of breast, lung, colorectal, ovarian, and endometrial cancer.
American journal of epidemiology - 15 Jun 2013
Dahabreh Issa J, Schmid Christopher H, Lau Joseph, Varvarigou Vasileia, Murray Samuel, Trikalinos Thomas A
Abstract excerpt
Preferential loss of heterozygosity at the rs1042522 locus of the tumor protein 53 gene (TP53) (Arg72Pro) is observed in several tumors. Genetic association studies in oncology often use tumor tissue rather than unaffected tissue for genotyping; in such cases, loss of heterozygosity at the TP53 locus could lead to differential misclassification and could bias estimates of association. We searched multiple...
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