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Article

Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

1 Jul 2015

Abstract excerpt

Current therapies for chronic hepatitis B virus infection (CHB) - nucleos(t)ide analogue reverse transcriptase inhibitors and interferons - result in low rates of functional cure defined as sustained off-therapy seroclearance of hepatitis B surface antigen (HBsAg). One likely reason is the inability of these therapies to consistently and substantially reduce the levels of viral antigen production. Accumulated...

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PMID: 26129970
DOI: 10.1016/j.antiviral.2015.06.019

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