Article
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America - 7 Aug 2007
Rozema David B, Lewis David L, Wakefield Darren H, Wong So C, Klein Jason J, Roesch Paula L, Bertin Stephanie L, Reppen Tom W, Chu Qili, Blokhin Andrei V, Hagstrom James E, Wolff Jon A
Abstract excerpt
Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a therapeutic modality. Hepatocytes, the key parenchymal cells of the liver, are a particularly attractive target cell type for siRNA delivery given their central role in several infectious and metabolic disorders. We have developed a vehicle for the delivery of...
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