Article
[Genome-wide association studies: methodology and interpretation for clinicians].
Nederlands tijdschrift voor geneeskunde - 1 Jan 2014
Asselbergs Folkert W, van der Laan Sander W, de Bakker Paul I W
Abstract excerpt
Genome-wide association studies (GWAS) are performed to find associations between genetic variants (i.e. single-nucleotide polymorphisms) and diseases. This review describes the basic principles of GWAS. To date, GWAS have identified thousands of genetic variants associated with complex diseases and biological characteristics such as LDL cholesterol levels. GWAS can provide important insights into the underlying...
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