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Article

Technological advancements in functional interpretation of genome-wide association studies (GWAS) findings: bridging the gap to clinical translation.

FEBS letters - 1 Dec 2024

Aherrahrou Redouane, Kaikkonen Minna U

Abstract excerpt

Genome-wide association studies (GWAS) significantly advanced our understanding of the genetic underpinnings of diseases. However, challenges persist, particularly in interpreting non-coding variants in linkage disequilibrium that affect genes in disease-relevant cells. Addressing key obstacles-identifying causal variants, uncovering target genes, and understanding their network impact-is crucial. This graphical...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 38683017
DOI: 10.1002/1873-3468.14884
PMCID: PMC11627003

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