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Article

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.

Journal of the American Chemical Society - 6 May 2015

Kwan David H, Constantinescu Iren, Chapanian Rafi, Higgins Melanie A, Kötzler Miriam P, Samain Eric, Boraston Alisdair B, Kizhakkedathu Jayachandran N, Withers Stephen G

Abstract excerpt

Blood transfusions are critically important in many medical procedures, but the presence of antigens on red blood cells (RBCs, erythrocytes) means that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal reactions following transfusion. Enzymatic removal of the terminal N-acetylgalactosamine or galactose of A- or B-antigens, respectively, yields universal O-type...

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PMID: 25870881
DOI: 10.1021/ja5116088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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