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Article

Improving the thermal stability of lactate oxidase by directed evolution.

Cellular and molecular life sciences : CMLS - 1 Jan 2007

Minagawa H, Yoshida Y, Kenmochi N, Furuichi M, Shimada J, Kaneko H

Abstract excerpt

Lactate oxidase is used in biosensors to measure the concentration of lactate in the blood and other body fluids. Increasing the thermostability of lactate oxidase can significantly prolong the lifetime of these biosensors. We have previously obtained a variant of lactate oxidase from Aerococcus viridans with two mutations (E160G/V198I) that is significantly more thermostable than the wild-type enzyme. Here we...

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Identifiers

PMID: 17131051
DOI: 10.1007/s00018-006-6409-8
PMCID: PMC11136210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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