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Article

Directed evolution of a soluble human IL-17A receptor for the inhibition of psoriasis plaque formation in a mouse model.

Chemistry & biology - 21 Feb 2013

Zaretsky Marianna, Etzyoni Revital, Kaye Joel, Sklair-Tavron Liora, Aharoni Amir

Abstract excerpt

Interleukin-17 (IL-17) is a T-cell-derived cytokine that promotes inflammatory pathology in autoimmune diseases. Blocking IL-17A interactions with its endogenous IL-17 receptor (IL-17RA) can constitute an important target for therapeutic intervention. Here, we utilized a directed evolution approach to generate soluble IL-17RA mutants that exhibit increased IL-17A binding affinity and thermostability, relative to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23438749
DOI: 10.1016/j.chembiol.2012.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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