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Article

IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model

28 Feb 2014

Abstract excerpt

BACKGROUND: IL-17 is the defining cytokine of the Th17, Tc17, and γδ T cell populations that plays a critical role in mediating inflammation and autoimmunity. Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines with relevant contributions of IFN-γ, TNF-α, and IL-17. Despite the pivotal role IL-17 plays in psoriasis, and in contrast to the other key mediators involved in the...

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PMID: 24587313
DOI: 10.1371/journal.pone.0090284

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