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The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties

15 Aug 2017

Abstract excerpt

IL-17A and IL-17F are prominent members of the IL-17 family of cytokines that regulates both innate and adaptive immunity. IL-17A has been implicated in chronic inflammatory and autoimmune diseases, and anti-IL-17A antibodies have shown remarkable clinical efficacy in psoriasis and psoriatic arthritis patients. IL-17A and IL-17F are homodimeric cytokines that can also form the IL-17A/F heterodimer whose precise...

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PMID: 28827714
DOI: 10.1038/s41598-017-08360-9

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