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Article

Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations.

Traffic (Copenhagen, Denmark) - 1 Jan 2004

Roselli Séverine, Moutkine Imane, Gribouval Olivier, Benmerah Alexandre, Antignac Corinne

Abstract excerpt

Podocytes are specialized epithelial cells of the glomerulus in the kidney, which interconnect at the top of the glomerular basement membrane through the slit diaphragm, an adherens-like junction that plays a crucial role in the glomerular filtration process. Podocin, a plasma membrane anchored s...

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Source

Identifiers

PMID: 14675423
DOI: 10.1046/j.1600-0854.2003.00148.x

Genes

NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14675423-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations.PMID 14675423Read ↗

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.Semantic proximity Read ↗

NPHS2 (Podocin) mutations in nephrotic syndrome. Clinical spectrum and fine mechanisms.Semantic proximity Read ↗

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems.Semantic proximity Read ↗

In silico Structural characterization of podocin and assessment of nephrotic syndrome-associated podocin mutants.Semantic proximity Read ↗

Endoplasmic reticulum-retained podocin mutants are massively degraded by the proteasome.Semantic proximity Read ↗

Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking.Semantic proximity Read ↗

Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membraneSemantic proximity Read ↗

Foothold of NPHS2 mutations in primary nephrotic syndrome.Semantic proximity Read ↗

A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.Semantic proximity Read ↗

Interaction with Podocin Facilitates Nephrin SignalingSemantic proximity Read ↗

R168H and V165X mutant podocin might induce different degrees of podocyte injury via different molecular mechanisms.Semantic proximity Read ↗

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