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Article

Attenuation of tick-borne encephalitis virus using large-scale random codon re-encoding.

PLoS pathogens - 1 Mar 2015

de Fabritus Lauriane, Nougairède Antoine, Aubry Fabien, Gould Ernest A, de Lamballerie Xavier

Abstract excerpt

Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was applied to the pathogenic flavivirus, tick-borne encephalitis virus (TBEV) which causes febrile illness and encephalitis in humans in forested regions of Europe and Asia. Using an infectious clone of the Oshima 5-10 strain ("wild-type virus"), a cassette of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enzyme-Linked Immunosorbent Assay

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Source

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Identifiers

PMID: 25734338
DOI: 10.1371/journal.ppat.1004738
PMCID: PMC4348424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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