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Article

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.

Nature genetics - 1 Apr 2007

Menne Tobias F, Goyenechea Beatriz, Sánchez-Puig Nuria, Wong Chi C, Tonkin Louise M, Ancliff Philip J, Brost Renée L, Costanzo Michael, Boone Charles, Warren Alan J

Abstract excerpt

The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the highly conserved Shwachman-Bodian-Diamond syndrome (SBDS) protein. Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17353896
DOI: 10.1038/ng1994

Genes

SBDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.PMID 17353896Read ↗

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.Semantic proximity Read ↗

EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndromeSemantic proximity Read ↗

Defective ribosome assembly in Shwachman-Diamond syndrome.Semantic proximity Read ↗

Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome.Semantic proximity Read ↗

The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast.Semantic proximity Read ↗

Impaired ribosomal subunit association in Shwachman-Diamond syndromeSemantic proximity Read ↗

Somatic genetic rescue of a germline ribosome assembly defect.Semantic proximity Read ↗

Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responsesSemantic proximity Read ↗

Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome.Semantic proximity Read ↗

Hog1/p38 and ZAKα drive Shwachman-Diamond syndrome and provide targets to improve cell growthSemantic proximity Read ↗

The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.Semantic proximity Read ↗

The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.Semantic proximity Read ↗

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