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Article

HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development.

Cancer discovery - 1 May 2018

de Bock Charles E, Demeyer Sofie, Degryse Sandrine, Verbeke Delphine, Sweron Bram, Gielen Olga, Vandepoel Roel, Vicente Carmen, Vanden Bempt Marlies, Dagklis Antonis, Geerdens Ellen, Bornschein Simon, Gijsbers Rik, Soulier Jean, Meijerink Jules P, Heinäniemi Merja, Teppo Susanna, Bouvy-Liivrand Maria, Lohi Olli, Radaelli Enrico, Cools Jan

Abstract excerpt

Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic precursor cells. However, how these events cooperate during oncogenic transformation remains poorly understood. We studied the cooperation between activated JAK3/STAT5 signaling and HOXA9 overexpression, two events identified as significantly co-occurring in T-cell acute lymphoblastic leukemia. Expression of mutant JAK3 and HOXA9...

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Source

Identifiers

PMID: 29496663
DOI: 10.1158/2159-8290.CD-17-0583

Genes

HOXA9
JAK3
FOS
JUN
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development.PMID 29496663Read ↗

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