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Article

Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status.

PloS one - 1 Jan 2013

Cesano Alessandra, Putta Santosh, Rosen David B, Cohen Aileen C, Gayko Urte, Mathi Kavita, Woronicz John, Hawtin Rachael E, Cripe Larry, Sun Zhuoxin, Tallman Martin S, Paietta Elisabeth

Abstract excerpt

FMS-like tyrosine kinase 3 receptor (FLT3) internal tandem duplication (ITD) mutations result in constitutive activation of this receptor and have been shown to increase the risk of relapse in patients with acute myeloid leukemia (AML); however, substantial heterogeneity in clinical outcomes stil...

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Identifiers

PMID: 23431389
DOI: 10.1371/journal.pone.0056714
PMCID: PMC3576376

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23431389-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status.PMID 23431389Read ↗

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Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia.Semantic proximity Read ↗

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature.Semantic proximity Read ↗

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth.Semantic proximity Read ↗

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