Article

Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

2023-06-22

Abstract excerpt

<h4>Summary</h4> Currently, the identification of patient-specific therapies in cancer is mainly informed by personalized genomic analysis. In the setting of acute myeloid leukemia (AML), patient-drug treatment matching fails in a subset of patients harboring atypical internal tandem duplications (ITDs) in the tyrosine kinase domain of the FLT3 gene. To address this unmet medical need, here we develop a systems-b...

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Literature Corpus work: dceb9650-bfda-587c-b376-24631ffdf144
DOI: 10.1101/2023.06.22.546072

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