Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant.

doi:10.1007/s10549-013-2448-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant.

Breast cancer research and treatment - 1 Apr 2013

Obazee Ofure, Justenhoven Christina, Winter Stefan, Chang-Claude Jenny, Rudolph Anja, Seibold Petra, Flesch-Janys Dieter, Hannelius Ulf, Li Jingmei, Humphreys Keith, Hall Per, Giles Graham, Severi Gianluca, Baglietto Laura, Southey Melissa, Rabstein Sylvia, Harth Volker, Lotz Anne, Pesch Beate, Brüning Thomas, Baisch Christian, Ko Yon-Dschun, Hamann Ute, Brauch Hiltrud

Abstract excerpt

17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) plays an important role in the biosynthesis of 17β-estradiol. The current study aimed at confirming the reduced risk of breast cancer in carriers of the non-synonymous HSD17B1_937_A>G (rs605059) polymorphism who used any hormone replacement therapy (HRT) for 10 years or longer. We performed an independent association study using four breast cancer case-control...

Topics

Breast Neoplasms
Case-Control Studies
Estradiol Dehydrogenases
Estrogen Replacement Therapy
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Frequency

Genetic Predisposition to Disease

Heterozygote

Humans

Polymorphism, Single Nucleotide

Postmenopause

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 23430226
DOI: 10.1007/s10549-013-2448-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.