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Article

Endurance training ameliorates the metabolic and performance characteristics of circadian Clock mutant mice.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2013

Pastore Stephen, Hood David A

Abstract excerpt

Circadian locomotor output cycles kaput (CLOCK) is a nuclear transcription factor that is a component of the central autoregulatory feedback loop that governs the generation of biological rhythms. Homozygous Clock mutant mice contain a truncated CLOCK(Δ19) protein within somatic cells, subsequently causing an impaired ability to rhythmically transactivate circadian genes. The present study sought to investigate...

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Source

Identifiers

PMID: 23429867
DOI: 10.1152/japplphysiol.01505.2012

Genes

CLOCK
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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