Article
Impaired exercise tolerance, mitochondrial biogenesis, and muscle fiber maintenance in miR‐133a–deficient mice
25 Jul 2016
Abstract excerpt
Exercise promotes multiple beneficial effects on muscle function, including induction of mitochondrial biogenesis. miR-133a is a muscle-enriched microRNA that regulates muscle development and function. The role of miR-133a in exercise tolerance has not been fully elucidated. In the current study, mice that were deficient in miR-133a demonstrated low maximal exercise capacity and low resting metabolic rate....
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