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Article

p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content.

Circulation research - 25 Sept 2009

Park Joon-Young, Wang Ping-Yuan, Matsumoto Takumi, Sung Ho Joong, Ma Wenzhe, Choi Jeong W, Anderson Stasia A, Leary Scot C, Balaban Robert S, Kang Ju-Gyeong, Hwang Paul M

Abstract excerpt

RATIONALE: Exercise capacity is a physiological characteristic associated with protection from both cardiovascular and all-cause mortality. p53 regulates mitochondrial function and its deletion markedly diminishes exercise capacity, but the underlying genetic mechanism orchestrating this is unclear. Understanding the biology of how p53 improves exercise capacity may provide useful insights for improving both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19696408
DOI: 10.1161/CIRCRESAHA.109.205310
PMCID: PMC2761626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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