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Article

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2008

Duan Junhui, Mu Jianbing, Thera Mahamadou Ali, Joy Deirdre, Kosakovsky Pond Sergei L, Diemert David, Long Carole, Zhou Hong, Miura Kazutoyo, Ouattara Amed, Dolo Amagana, Doumbo Ogobara, Su Xin-Zhuan, Miller Louis

Abstract excerpt

Immunization with the highly polymorphic Plasmodium falciparum apical membrane antigen 1 (PfAMA1) induces protection in animals but primarily against parasites that express the same or similar alleles. One strategy to overcome the obstacle of polymorphism is to combine PfAMA1 proteins representing major haplotypes into one vaccine. To determine the minimum number of haplotypes that would confer broad protection,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18515425
DOI: 10.1073/pnas.0802328105
PMCID: PMC2409418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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