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Article

Ligand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide.

The Journal of biological chemistry - 14 Sept 2012

Rathmann Daniel, Lindner Diana, DeLuca Stephanie H, Kaufmann Kristian W, Meiler Jens, Beck-Sickinger Annette G

Abstract excerpt

The prolactin-releasing peptide receptor and its bioactive RF-amide peptide (PrRP20) have been investigated to explore the ligand binding mode of peptide G-protein-coupled receptors (GPCRs). By receptor mutagenesis, we identified the conserved aspartate in the upper transmembrane helix 6 (Asp(6.59)) of the receptor as the first position that directly interacts with arginine 19 of the ligand (Arg(19)). Replacement...

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Identifiers

PMID: 22778259
DOI: 10.1074/jbc.M112.349852
PMCID: PMC3442549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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