Article
The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans.
Nature - 31 May 1990
Chalfie M, Wolinsky E
Abstract excerpt
The dominant mutation deg-1(u38) results in a toxic gene product that leads to the late-onset degeneration of a small number of neurons in the nematode Caenorhabditis elegans. Both intragenic and extragenic mutations as well as changes in wild-type gene dosage can delay or block the time of onset...
Topics
- Age Factors
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis
- Cloning, Molecular
- Gene Expression
- Genes
- Genes, Dominant
- Membrane Proteins
- Molecular Sequence Data
- Nerve Degeneration
- Phenotype
- Suppression, Genetic