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Article

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans.

Nature - 31 May 1990

Chalfie M, Wolinsky E

Abstract excerpt

The dominant mutation deg-1(u38) results in a toxic gene product that leads to the late-onset degeneration of a small number of neurons in the nematode Caenorhabditis elegans. Both intragenic and extragenic mutations as well as changes in wild-type gene dosage can delay or block the time of onset of the neuronal deaths. The deg-1 gene has been cloned and a partial complementary DNA reveals that the gene encodes a...

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PMID: 2342572
DOI: 10.1038/345410a0

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