Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons.

Genetics - 1 Mar 1995

Shreffler W, Magardino T, Shekdar K, Wolinsky E

Abstract excerpt

Two Caenorhabditis elegans genes, unc-8 and sup-40, have been newly identified, by genetic criteria, as regulating ion channel function in motorneurons. Two dominant unc-8 alleles cause motorneuron swelling similar to that of other neuronal types in dominant mutants of the deg-1 gene family, which is homologous to a mammalian gene family encoding amiloride-sensitive sodium channel subunits. As for previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7539392
DOI: 10.1093/genetics/139.3.1261
PMCID: PMC1206455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons.PMID 7539392Read ↗

Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Semantic proximity Read ↗

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans.Semantic proximity Read ↗

Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance.Semantic proximity Read ↗

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.Semantic proximity Read ↗

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.Semantic proximity Read ↗

sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.Semantic proximity Read ↗

The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2.Semantic proximity Read ↗

MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.Semantic proximity Read ↗

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.Semantic proximity Read ↗

Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.Semantic proximity Read ↗

Neuropathology of degenerative cell death in Caenorhabditis elegans.Semantic proximity Read ↗

A Gain-of-Function Mutation in NALCN in a Child with Intellectual Disability, Ataxia, and Arthrogryposis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.