Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism -116C/G of human X-box-binding protein 1 promoter is associated with risk of Alzheimer's disease.

CNS neuroscience & therapeutics - 1 Apr 2013

Liu Sheng-Yuan, Wang Wei, Cai Zhi-You, Yao Li-Fen, Chen Zhong-Wei, Wang Chang-Yi, Zhao Bin, Li Ke-Shen

Abstract excerpt

AIM: Alzheimer's disease (AD) is a multifactor disease that has been reported to have a close association with endoplasmic reticulum (ER) stress response. In the response, the regulator factor human X-box-binding protein 1 (XBP1) has been shown to facilitate the refolding and degradation of misfolded proteins, prevent neurotoxicity of amyloid-beta (Aβ) and tau, and play an important role in the survival of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to DNA-Binding Proteins

Share to Genetic Markers

Share to Regulatory Factor X Transcription Factors

Share to Transcription Factors

Share to X-Box Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23421912
DOI: 10.1111/cns.12064
PMCID: PMC6493550

Genes

XBP1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism -116C/G of human X-box-binding protein 1 promoter is associated with risk of Alzheimer's disease.PMID 23421912Read ↗

Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population.Semantic proximity Read ↗

Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and atherosclerosis, ischemic stroke and hyperhomocysteinemia.Semantic proximity Read ↗

The -116C/G polymorphism in XBP1 gene is associated with psychiatric illness in Asian population: A meta-analysis.Semantic proximity Read ↗

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.Semantic proximity Read ↗

Association between polymorphisms in Interleukin-16 gene and risk of late-onset Alzheimer's disease.Semantic proximity Read ↗

Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia.Semantic proximity Read ↗

Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia.Semantic proximity Read ↗

X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset.Semantic proximity Read ↗

Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and obesity.Semantic proximity Read ↗

Association of X-box binding protein 1 ( XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episode.Semantic proximity Read ↗

Preliminary evidence on the association between XBP1-116C/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders.Semantic proximity Read ↗

A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.