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Article

Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population.

Psychiatry and clinical neurosciences - 1 Aug 2004

Kakiuchi Chihiro, Ishiwata Mizuho, Umekage Tadashi, Tochigi Mamoru, Kohda Kazuhisa, Sasaki Tsukasa, Kato Tadafumi

Abstract excerpt

Schizophrenia and bipolar disorder share some clinical features and linkage studies have shown that several loci are common. Recently, the authors found that the -116C-->G substitution in the promotor region of XBP1, a pivotal gene in endoplasmic reticulum (ER) stress response, causes the impairment of ER stress response, and that the -116C/C genotype is a protective factor; in other words the presence of the G...

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Source

Identifiers

PMID: 15298659
DOI: 10.1111/j.1440-1819.2004.01280.x

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population.PMID 15298659Read ↗

The -116C/G polymorphism in XBP1 gene is associated with psychiatric illness in Asian population: A meta-analysis.Semantic proximity Read ↗

Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia.Semantic proximity Read ↗

A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder.Semantic proximity Read ↗

Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia.Semantic proximity Read ↗

Polymorphism -116C/G of human X-box-binding protein 1 promoter is associated with risk of Alzheimer's disease.Semantic proximity Read ↗

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.Semantic proximity Read ↗

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