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Article

Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and obesity.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Feb 2010

Yilmaz Erkan, Berberoglu Merih, Akar Nejat

Abstract excerpt

Endoplasmic reticulum stress is a central feature of obesity, insulin resistance, and type 2 diabetes. A polymorphism of the XBP1 gene (-116C/G), a transcription factor that modulates the endoplasmic reticulum stress response, causes an impairment of its positive feedback system. The authors examined a role of the polymorphism in the development of obesity. The polymorphism was investigated in clinically obese...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18840627
DOI: 10.1177/1076029608323498

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and obesity.PMID 18840627Read ↗

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The -116C/G polymorphism in XBP1 gene is associated with psychiatric illness in Asian population: A meta-analysis.Semantic proximity Read ↗

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