Article
X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset.
Neuroscience letters - 2 Sept 2004
Hou Sheue-Jane, Yen Feng-Chang, Cheng Chih-Ya, Tsai Shih-Jen, Hong Chen-Jee
Abstract excerpt
X-box binding protein 1 (XBP1), a critical gene in the endoplasmic reticulum stress response, is located on chromosome 22q12, which has been linked with bipolar disorders in several studies. Recently, associations have been reported between a polymorphism (-116C --> G) in the promoter region of XBP1, and bipolar disorders in both case-control study and family-based association study, however, this finding is not...
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