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Article

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.

Nature genetics - 1 Oct 2003

Kakiuchi Chihiro, Iwamoto Kazuya, Ishiwata Mizuho, Bundo Miki, Kasahara Takaoki, Kusumi Ichiro, Tsujita Takahiro, Okazaki Yuji, Nanko Shinichiro, Kunugi Hiroshi, Sasaki Tsukasa, Kato Tadafumi

Abstract excerpt

The pathophysiology of bipolar disorder is still unclear, although family, twin and linkage studies implicate genetic factors. Here we identified XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, as contributing to the genetic risk factor for bipolar disorder. Using DNA micr...

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Source

Identifiers

PMID: 12949534
DOI: 10.1038/ng1235

Genes

XBP1
ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12949534-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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