Article
A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder.
The international journal of neuropsychopharmacology - 1 Feb 2006
Masui Takuya, Hashimoto Ryota, Kusumi Ichiro, Suzuki Katsuji, Tanaka Teruaki, Nakagawa Shin, Kunugi Hiroshi, Koyama Tsukasa
Abstract excerpt
Bipolar disorder (BPD) is a severe, chronic, and life-threatening illness, and its pathogenesis remains unclear. Recently, a functional polymorphism (-116C/G) of the X-box binding protein 1 (XBP1) gene was reported to be a genetic risk factor for BPD. Moreover, the endoplasmic reticulum stress responses were impaired in cultured lymphocytes from BPD patients with the -116G allele and only valproate rescued such...
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