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Article

Reducing dynamin 2 (DNM2) rescues DNM2 -related dominant centronuclear myopathy

5 Oct 2018

Abstract excerpt

Significance Centronuclear myopathies are rare and severe congenital muscle diseases. Here we hypothesized that reducing dynamin 2 (DNM2) may rescue the pathophysiology observed in DNM2 -related dominant centronuclear myopathy. The total DNM2 expression was reduced in a faithful murine model ( Dnm2 RW/+ mice) using two different methods targeting both mutated and wild-type Dnm2 , adeno-associated virus-shRNA, or...

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PMID: 30291191
DOI: 10.1073/pnas.1808170115

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