Article
Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.
Journal of lipid research - 1 Mar 1990
Wardell M R, Rall S C, Brennan S O, Nye E R, George P M, Janus E D, Weisgraber K H
Abstract excerpt
Homozygosity for the apolipoprotein (apo) E variant apoE2(158 Arg----Cys) invariably gives rise to dysbetalipoproteinemia, and when associated with obesity or a gene for hyperlipidemia, results in type III hyperlipoproteinemia. The association of the E2/2 phenotype with type IV/V hyperlipoprotein...
Topics
- Amino Acid Sequence
- Apolipoprotein E2
- Apolipoproteins E
- Arginine
- Cysteine
- Diseases in Twins
- Electrophoresis, Gel, Two-Dimensional
- Genetic Variation
- Heterozygote
- Humans
- Hyperlipoproteinemia Type III
- Hyperlipoproteinemia Type V
- Lipoproteins
- Male
- Middle Aged
- Peptide Mapping
- Protein Conformation
- Receptors, LDL